B-054

Buspirone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₂₁H₃₁N₅O₂ · HCl
• Numéro CAS: 33386-08-2
• Poids moléculaire : 421.96
• Numéro MDL: MFCD00078569
• Code UNSPSC : 41116107
• ID de substance PubChem : 329773117
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: (Snap-N-Spike^®)
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL in methanol (as free base)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: O=C1CC2(CCCC2)CC(N1CCCCN(CC3)CCN3C4=NC=CC=N4)=O.Cl
• InChI: 1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
• Clé InChI: RICLFGYGYQXUFH-UHFFFAOYSA-N
• Informations sur le gène: human ... HTR1A(3350)

Description

Description générale

Buspirone, sold under the trade name Buspar^®, is an antidepressant marketed for treatment of generalized anxiety disorder and clinical depression. Suitable uses for this Certified Spiking Solution^®include as starting material for calibrators and controls in antidepressant testing methods by LC/MS or GC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

Application

• Optimization of Buspirone Hydrochloride-Loaded In Situ Gel for Pediatric Anxiety: This study utilized response surface methodology to develop an optimized formulation of buspirone hydrochloride in situ gel, specifically designed for pediatric anxiety treatment. (Abdallah et al., 2022).


• Behavioral Effects of Buspirone in Juvenile Zebrafish: Investigating the behavioral effects of buspirone on juvenile zebrafish of two different genetic backgrounds, this study highlights the potential of buspirone hydrochloride solution to serve as a critical tool in neuropharmacological research, especially in studying anxiolytic compounds and their mechanisms of action within the GABAergic system (Abozaid et al., 2022).


• Nasal Delivery System for Buspirone Hydrochloride: Focused on the development of buspirone hydrochloride-loaded nanovesicular gels for nasal delivery, this research explores an innovative approach to administering psychiatric medication, providing a promising alternative to traditional oral routes. This method could potentially enhance the bioavailability and onset of action of buspirone, making it more effective for treating anxiety disorders (Abdelnabi et al., 2019).

Informations légales

Buspar is a registered trademark of Bristol-Myers Squibb Co.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225 - H301 + H311 + H331 - H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup