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F5396

Sigma-Aldrich

Fenbendazole

≥98%

Synonyme(s) :

5-(Phénylthio)-2-benzimidazolecarbamate de méthyle

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About This Item

Formule empirique (notation de Hill):
C15H13N3O2S
Numéro CAS:
43210-67-9
Poids moléculaire :
299.35
Numéro Beilstein :
759077
Numéro CE :
256-145-7
Numéro MDL:
MFCD00144301
Code UNSPSC :
12352100
ID de substance PubChem :
57654186
Nomenclature NACRES :
NA.22

Pureté

≥98%

Chaîne SMILES 

COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1

InChI

1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)

Clé InChI

HDDSHPAODJUKPD-UHFFFAOYSA-N

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Description générale

Fenbendazole also known as Methyl 5-(phenylthio)-2-benzimidazolecarbamate, is a benzimidazole anthelmintic and antiprotozoal agent.

Application


  • Fenbendazole in Veterinary Medicine: Investigated for efficacy against coccidicidal fungi in avian species, demonstrating broad-spectrum antiparasitic potential. Additionally, its environmental impact and pharmacokinetics reveal insights for sustainable agricultural practices and disease vector control. (Lozano et al., 2024), (Hachgenei et al., 2024), (Durden et al., 2023).

  • Food safety and allergen detection: Fenbendazole′s implications in food safety are explored through quantitative PCR methods for detecting allergenic species in foods, underscoring the importance of accurate detection techniques in food industry compliance and safety standards (Costa et al., 2023).

  • Analysis of antibiotic and anthelmintic residues: The occurrence and exposure evaluation of Fenbendazole residues in cow milk in China is studied, emphasizing the need for rigorous monitoring of food products to ensure public health safety (Chang et al., 2023).


Pictogrammes

Health hazardEnvironment
GHS08,GHS09

Mention d'avertissement

Warning

Mentions de danger

H361fd,H373,H410

Classification des risques

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2

Organes cibles

Liver,lymph node,Stomach,Nervous system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Penny K Patten et al.
Veterinary clinical pathology, 42(1), 103-108 (2013-01-03)
Mesocestoides cestode infections in dogs are well known for causing severe peritonitis with larvae or larval fragments (metacestodes, tetrathyridia, or calcareous corpuscles) frequently observed cytologically in peritoneal fluid samples. This case report describes the cytologic and clinical features of 2
C Chassaing et al.
Journal of medicinal chemistry, 51(5), 1111-1114 (2008-02-15)
Highly water-soluble prodrugs 1a- g of anthelmintic benzimidazole carbamates 2a- g were synthesized. These prodrugs combine high aqueous solubility and stability with high lability in the presence of alkaline phosphatases. The veterinary utility of 1a was shown by a pharmacodynamic
Nilambra Dogra et al.
The Journal of biological chemistry, 287(36), 30625-30640 (2012-06-30)
In recent years, there has been a great deal of interest in proteasome inhibitors as a novel class of anticancer drugs. We report that fenbendazole (FZ) (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate) exhibits a potent growth-inhibitory activity against cancer cell lines but not normal
Niels C Kyvsgaard et al.
Veterinary parasitology, 181(2-4), 248-254 (2011-05-17)
Horses, mules and donkeys are indispensable farming and working animals in many developing countries, and their health status is important to the farmers. Strongyle parasites are ubiquitous in grazing horses world-wide and are known to constitute a threat to equine
Unexpected production loss caused by helminth parasites in weaned beef calves.
N D Sargison et al.
The Veterinary record, 167(19), 752-754 (2011-01-25)
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