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429066

(3-Bromopropoxy)-tert-butyldimethylsilane

Name: (3-Bromopropoxy)-<I>tert</I>-butyldimethylsilane
Brand: ALDRICH

97%

Synonyme(s) :

(3-Bromopropoxy)(1,1-dimethylethyl)dimethylsilane, 1-((tert-Butyldimethylsilyl)oxy)-3-bromopropane, 1-Bromo-3-(tert-butyldimethylsiloxy)propane, 1-Bromo-3-[(tert-butyldimethylsilanyl)oxy]propane, 1-Bromo-3-[(tert-butyldimethylsilyl)oxy]propane, 3-((tert-Butyldimethylsilyl)oxy)-1-bromopropane

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About This Item

Formule linéaire :

Br(CH₂)₃OSi(CH₃)₂C(CH₃)₃

Numéro CAS:

89031-84-5

Poids moléculaire :

253.25

Numéro MDL:

MFCD00216589

Code UNSPSC :

12352100

ID de substance PubChem :

24866833

Nomenclature NACRES :

NA.22

Pureté

97%

Forme

liquid

Contient

sodium carbonate as stabilizer

Indice de réfraction

n20/D 1.451 (lit.)

Point d'ébullition

182 °C (lit.)

Densité

1.093 g/mL at 25 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES

CC(C)(C)[Si](C)(C)OCCCBr

InChI

1S/C9H21BrOSi/c1-9(2,3)12(4,5)11-8-6-7-10/h6-8H2,1-5H3

Clé InChI

QGMROEZDWJTIDW-UHFFFAOYSA-N

Description générale

(3-Bromopropoxy)-tert-butyldimethylsilane is a bromo silyl ether.

Application

(3-Bromopropoxy)-tert-butyldimethylsilane may be used to introduce propanol functionality to many pharmaceuticals.
It may be used as an alkylating agent in the synthesis of the following:

N-[2-[N-[3-(tert-butyldimethylsilyloxy)propyl]-N-ethylamino]ethyl]phthalimide
O-(3-tert-butyldimethylsilyloxypropyl)-N-(tert-butoxycarbonyl)-L-tyrosine methyl ester
tert-butyldimethyl-[3-(3-methyl-2-nitrophenoxy)propoxy]silane

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Conseils de prudence

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

185.0 °F - closed cup

Point d'éclair (°C)

85 °C - closed cup

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Synthesis of O-(3-[¹⁸F] Fluoropropyl)-L-tyrosine (L-[¹⁸F] FPT) and its biological evaluation in 9L tumor bearing rat.

Moon BS, et al.

Bull. Korean Chem. Soc., 26(1), 91-96 (2005)

Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.

Ramani R Ranatunge et al.

Journal of medicinal chemistry, 47(9), 2180-2193 (2004-04-16)

The synthesis of a series of novel pyrazoles containing a nitrate (ONO(2)) moiety as a nitric oxide (NO)-donor functionality is reported. Their COX-1 and COX-2 inhibitory activities in human whole blood are profiled. Our data demonstrate that pyrazole ring substituents

A concise total synthesis of (+/-)-vigulariol.

J Stephen Clark et al.

Angewandte Chemie (International ed. in English), 46(3), 437-440 (2006-12-06)

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

Han-Cheng Zhang et al.

Bioorganic & medicinal chemistry letters, 14(12), 3245-3250 (2004-05-20)

A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides was synthesized and evaluated for activity against GSK-3beta and selectivity versus PKC-betaII, as well as a broad panel of protein kinases. Compounds 14 and 17c potently inhibited GSK-3beta (IC(50)=7 and 26 nM, respectively) and

Synthesis, radioiodination and in vivo screening of novel potent iodinated and fluorinated radiotracers as melanoma imaging and therapeutic probes.

Maisonial A, et al.

European Journal of Organic Chemistry, 63, 840-853 (2013)

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