UBA7
ubiquitin-like modifier activating enzyme 7
- Human(7318) Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
- Mouse(74153) ubiquitin-like modifier activating enzyme 7
- Rat(301000) ubiquitin-like modifier activating enzyme 7
- chicken(395178) ubiquitin-like modifier activating enzyme 7
- domestic cat(101088821) ubiquitin-like modifier activating enzyme 7
- Horse(100052809) ubiquitin-like modifier activating enzyme 7
- dog(608118) ubiquitin-like modifier activating enzyme 7
- domestic guinea pig(100731595) ubiquitin-like modifier activating enzyme 7
- naked mole-rat(101719508) ubiquitin-like modifier activating enzyme 7
- Domestic Rabbit(100338238) ubiquitin-like modifier activating enzyme 7
- cow(497204) ubiquitin-like modifier activating enzyme 7
- sheep(101123668) ubiquitin-like modifier activating enzyme 7
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