SIRPA
signal-regulatory protein alpha
Synonymes:
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
Espèce(s):
Human SIRPA (140885), Mouse Sirpa (19261), Rat Sirpa (25528), cow SIRPA (327666), sheep SIRPA (101105677), domestic guinea pig Sirpa (100719630), naked mole-rat Sirpa (101706086), Domestic Rabbit SIRPA (100351485), chicken SIRPA (419267), dog SIRPA (609452) ...Plus
ID UniProtKB:
ID du gène:
- Human(140885) Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19261) signal-regulatory protein alpha
- Rat(25528) signal-regulatory protein alpha
- cow(327666) signal-regulatory protein alpha
- sheep(101105677) signal-regulatory protein alpha
- domestic guinea pig(100719630) signal-regulatory protein alpha
- naked mole-rat(101706086) signal-regulatory protein alpha
- Domestic Rabbit(100351485) signal-regulatory protein alpha
- chicken(419267) signal-regulatory protein alpha
- dog(609452) signal-regulatory protein alpha
- Horse(100067339) signal-regulatory protein alpha
- domestic cat(101084787) signal-regulatory protein alpha
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-SIRPA Antibody, clone 3N8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-SIRPA Antibody, clone MY-1, ,
Espèces réactives
mouse
Application
flow cytometry
immunofluorescence
immunoprecipitation (IP)
inhibition assay
western blot
immunofluorescence
immunoprecipitation (IP)
inhibition assay
western blot
Anti-Macrophages/Granulocytes Antibody, clone OX-41, clone OX-41, Chemicon®, from mouse,
Espèces réactives
human, mouse, rat
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-SIRPA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-CD172a/b antibody produced in mouse, clone SE5A5,
Espèces réactives
human
Application
flow cytometry