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SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

Synonymes:
BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(6337) Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
  • Mouse(20276) sodium channel, nonvoltage-gated 1 alpha
  • Rat(25122) sodium channel, nonvoltage-gated 1 alpha
  • cow(282348) sodium channel, non-voltage-gated 1 alpha subunit
  • sheep(443488) sodium channel, non-voltage-gated 1 alpha subunit
  • naked mole-rat(101700410) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic guinea pig(100135613) sodium channel, nonvoltage-gated 1 alpha
  • chicken(396050) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic cat(101091122) sodium channel, non-voltage-gated 1 alpha subunit
  • dog(403650) sodium channel, non-voltage-gated 1 alpha subunit

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Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Lidocaine, powder,
Espèce(s)
rat, human
Lamotrigine, ≥98%, powder,
Espèce(s)
rat, human
Lidocaine, analytical standard,
Espèce(s)
rat, human
5-(N,N-Dimethyl)amiloride hydrochloride, ,
Espèce(s)
rat, mouse, human
5-(N,N-Hexamethylene)amiloride, ,
Espèce(s)
rat, human, mouse

Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-ENaC alpha antibody produced in mouse, clone 14E10,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
Anti-SCNN1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Monoclonal Anti-ENaC alpha-FITC antibody produced in mouse, clone 14E10,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-ENaC alpha antibody produced in mouse, clone 2G4,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
Anti-SCNN1A antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Triamterene, ≥99%,
Espèce(s)
human
Triamterene, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Triamterene, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Triamterene, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
Triamterene, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Benzamil hydrochloride hydrate, ≥98% (HPLC),
Espèce(s)
mouse, rat, human
Phenamil methanesulfonate salt, solid,
Espèce(s)
mouse, rat, human
5-(N-Methyl-N-isobutyl)­amiloride, ≥98% (TLC), powder,
Espèce(s)
mouse, rat, human
Lidocaine, powder,
Espèce(s)
rat, human
Lidocaine, analytical standard,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human SCNN1A,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Scnn1a,
Espèce(s)
mouse