RAG2
recombination activating gene 2
Synonymes:
RAG-2
Espèce(s):
Human RAG2 (5897), Mouse Rag2 (19374), Rat Rag2 (295953), domestic guinea pig Rag2 (100723894), Domestic Rabbit RAG2 (100328951), naked mole-rat Rag2 (101724205), cow RAG2 (782387), sheep RAG2 (101107628), Zebrafish rag2 (30658), domestic cat RAG2 (101096513) ...Plus
ID UniProtKB:
ID du gène:
- Human(5897) Summary: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
- Mouse(19374) recombination activating gene 2
- Rat(295953) recombination activating gene 2
- domestic guinea pig(100723894) recombination activating gene 2
- Domestic Rabbit(100328951) recombination activating gene 2
- naked mole-rat(101724205) recombination activating gene 2
- cow(782387) recombination activating gene 2
- sheep(101107628) recombination activating gene 2
- Zebrafish(30658) recombination activating gene 2
- domestic cat(101096513) recombination activating gene 2
- domestic cat(493757) recombination activating gene 2
- dog(483419) recombination activating gene 2
- chicken(423165) recombination activating gene 2
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-RAG-2 Antibody, clone 39, culture supernatant, clone 39, from rabbit,
Espèces réactives
mouse
Application
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-RAG2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti- RAG2 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
esiRNA
Référence du produit
Description
Espèce(s)
