IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
Synonymes:
IDCD, IDH, IDP, IDPC, PICD
Espèce(s):
Human IDH1 (3417), Mouse Idh1 (15926), Rat Idh1 (24479), Zebrafish idh1 (100006589), chicken IDH1 (424112), dog IDH1 (478889), domestic cat IDH1 (751618), cow IDH1 (281235), Horse IDH1 (100066416), Thale Cress IDH1 (829679) ...Plus
ID UniProtKB:
ID du gène:
- Human(3417) Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]
- Mouse(15926) isocitrate dehydrogenase 1 (NADP+), soluble
- Rat(24479) isocitrate dehydrogenase 1 (NADP+), soluble
- Zebrafish(100006589) isocitrate dehydrogenase 1 (NADP+), soluble
- chicken(424112) isocitrate dehydrogenase 1 (NADP+), soluble
- dog(478889) isocitrate dehydrogenase 1 (NADP+), soluble
- domestic cat(751618) isocitrate dehydrogenase 1 (NADP+), soluble
- cow(281235) isocitrate dehydrogenase 1 (NADP+), soluble
- Horse(100066416) isocitrate dehydrogenase 1 (NADP+), soluble
- Thale Cress(829679) Isocitrate dehydrogenase [NAD] regulatory subunit 1
- sheep(443257) isocitrate dehydrogenase 1 (NADP+), soluble
- Domestic Rabbit(100328559) isocitrate dehydrogenase 1 (NADP+), soluble
- domestic guinea pig(100729107) isocitrate dehydrogenase 1 (NADP+), soluble
- naked mole-rat(101705662) isocitrate dehydrogenase 1 (NADP+), soluble
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Antibodies
Référence du produit
Description
Espèces réactives
Application
IDH1 R132H (MRQ-67) Rabbit Monoclonal Antibody, ,
Espèces réactives
Application
immunohistochemistry
Anti-IDH1 (R132H) antibody, Mouse monoclonal, clone HMab-1, purified from hybridoma cell culture,
Espèces réactives
human
Application
western blot
Anti-IDH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anticorps anti-isocitrate déshydrogénase 1 (IDH1)-R132H, clone HMab-1, clone HMab-1, from mouse,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-IDH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Kits
Référence du produit
Description
Espèce(s)