HTR2C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Synonymes:
5-HT2C, 5-HTR2C, HTR1C
Espèce(s):
Human HTR2C (3358), Mouse Htr2c (15560), Rat Htr2c (25187), naked mole-rat Htr2c (101726296), chicken HTR2C (428707), cow HTR2C (538909), Horse HTR2C (100057852), domestic cat HTR2C (101099620), dog HTR2C (450240)
ID UniProtKB:
ID du gène:
- Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
- Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
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Small Molecule - Agonist
Référence du produit
Description
Espèce(s)
Small Molecule - Allosteric Modulator
Référence du produit
Description
Espèce(s)
Small Molecule - Antagonist
Référence du produit
Description
Espèce(s)
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
canine, human, mouse, rat
Application
ELISA
western blot
western blot
Small Molecule - Blocker
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human
Small Molecule - Ligand
Référence du produit
Description
Espèce(s)
Small Molecule - Metabolite
Référence du produit
Description
Espèce(s)
Small Molecule - Mixed Agonist/Antagonist
Small Molecule - Precursor
Référence du produit
Description
Espèce(s)
Proteins
Référence du produit
Description
Espèce(s)
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Espèce(s)
human
esiRNA
Référence du produit
Description
Espèce(s)