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HLA-B

major histocompatibility complex, class I, B

Synonymes:
AS, HLAB, SPDA1
Espèce(s):
Human HLA-B (3106)
ID UniProtKB:
P30464, B0V0B8, P30465, P30513, Q29633, Q29636, Q29829, Q29953
ID du gène:
  • Human(3106) Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

Référence du produit
Description
Espèces réactives
Application
MAB1288
Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate, clone BB7.1, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
MAB1285FX
Anti-HLA-B27 Antibody, clone HLA.ABC.m3, FITC conjugated, clone HLA.ABC.m3, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
MAB1285
Anti-HLA-B27 Antibody, clone HLA.ABC.m3, clone HLA.ABC.m3, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry
MAB1285F
Anti-HLA-B27 Antibody, clone HLA.ABC.m3, FITC conjugated, clone HLA.ABC.m3, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
immunofluorescence
SAB1410631
Anti-HLA-B antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot