FLT3
fms-related tyrosine kinase 3
Synonymes:
CD135, FLK-2, FLK2, STK1
Espèce(s):
Human FLT3 (2322), Mouse Flt3 (14255), Rat Flt3 (140635), Zebrafish flt3 (566708), chicken FLT3 (100858422), cow FLT3 (512700), Horse FLT3 (100061780), domestic cat FLT3 (101099264), dog FLT3 (486025), domestic guinea pig Flt3 (100732047) ...Plus
ID UniProtKB:
ID du gène:
- Human(2322) Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
- Mouse(14255) FMS-like tyrosine kinase 3
- Rat(140635) fms-related tyrosine kinase 3
- Zebrafish(566708) fms-related tyrosine kinase 3
- chicken(100858422) fms-related tyrosine kinase 3
- cow(512700) fms-related tyrosine kinase 3
- Horse(100061780) fms-related tyrosine kinase 3
- domestic cat(101099264) fms-related tyrosine kinase 3
- dog(486025) fms-related tyrosine kinase 3
- domestic guinea pig(100732047) fms-related tyrosine kinase 3
- naked mole-rat(101713724) fms-related tyrosine kinase 3
- sheep(101112331) fms-related tyrosine kinase 3
- Domestic Rabbit(100342842) fms-related tyrosine kinase 3
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-FLT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-FLT3 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse
Application
ELISA
western blot
western blot
Anti-FLT3 (Ab-591) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Monoclonal Anti-FLT3 antibody produced in mouse, clone 3H1, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunofluorescence
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Proteins
Référence du produit
Description
Espèce(s)
Flt-3/Flk-2 ligand human, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC),
Espèce(s)
human
FLT3 (571-993), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human
Flt3 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE),
Espèce(s)
human
Flt-3 Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3, amino acids 564 -end. For use in Kinase Assays.,
Espèce(s)
human
Flt-3 (D835Y) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.,
Espèce(s)
human