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MilliporeSigma

Build with Better Bases

Reliable oligonucleotide reagents from a supplier with greater capacity, custom capabilities and packaging, QA & documentation, and complete support of your most demanding project.

Reagents for Oligonucleotide Synthesis

The Proligo® reagents portfolio offers a full range of phosphoramidites, solid supports, and liquid reagents for oligonucleotide synthesis that include the following features:

  • High-quality standard and specialized products for the complete workflow
  • Flexible and customizable production and packaging options
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Proligo® Catalog

Featuring all product and technical information associated with the Proligo® Reagents range.

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Workflow

Synthesis Supports

Synthesis Supports

Controlled Pore Glass (CPG) has proven to be the most accepted supports for the chemical synthesis of DNA and RNA. Features include high surface area, efficient mass transfer and chemical inertness.

Detritylation & Activation

Coupling takes place once the DMT groups are removed through the detritylation mechanism utilizing TCA.

Activator solutions are mixed with solutions of phosphoramidites during the extension step.

Coupling

Phosphoramidite monomers are added through the coupling mechanism utilizing the following products:

Capping & Oxidation

Stabilization of the reactions and efficiency of the yield is achieved through oxidation and capping.

Supporting Technical Documents

Highlights

Quality Assurance
Quality Assurance

Dedicated process technology group and in-process controls that will adapt to evolving diagnostic and pharmaceutical requirements.

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State-of-the-Art Production
State-of-the-Art Production

Complete packaging services from routine to custom and from milligrams to kilograms at our state-of-the-Art Manufacturing facility in Hamburg.

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