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  • Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells.

Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells.

Experimental cell research (2017-02-16)
Qipeng Wu, Bei Yao, Ning Li, Lei Ma, Yanchao Deng, Yang Yang, Cheng Zeng, Zhicheng Yang, Bing Liu
PMID28196727
ABSTRACT

The redox adaptation mechanisms in cancer cells are very complex and remain largely unclear. Our previous studies have confirmed that NADPH oxidase 4 (NOX4) is abundantly expressed in non-small cell lung cancer (NSCLC) and confers apoptosis resistance on NSCLC cells. However, the comprehensive mechanisms for NOX4-mediated oxidative resistance of cancer cells remain still undentified. The present study found that NOX4-derived H