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Synthesis of the spirosuccinimide moiety of Asperparaline A.

Bioscience, biotechnology, and biochemistry (2000-09-19)
S Tanimori, K Fukubayashi, M Kirihata
PMID10993171
ABSTRACT

2,6,6-Trimethyl-2-azaspiro[4.4]nonane-1,3-dione (9), a spirosuccinimide moiety of asperparaline A (1), was synthesized by starting from 2,2-dimethylcyclopentanone (4) via trinitrile 6 in five steps in a moderate yield. This conversion establishes a model study for synthesis of the spirosuccinimide moiety of asperparaline A (1).

MATERIALS
Product Number
Brand
Product Description
371475
Sigma-Aldrich
2,2-Dimethylcyclopentanone, 96%