- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper - O.F.H.C., foil, 25x25mm, thickness 1.0mm, half hard, 99.95+%
Copper, insulated wire, 10m, conductor diameter 0.7mm, insulation thickness 0.01mm, polyurethane insulation
Copper, insulated wire, 10m, conductor diameter 0.05mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%
Copper - O.F.H.C., wire reel, 5m, diameter 2.0mm, hard, 99.95+%
Copper, mesh, 300x300mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh
Copper, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%
Copper, insulated wire, 10m, conductor diameter 0.24mm, insulation thickness 0.25mm, PTFE (polytetrafluoroethylene) insulation
Copper, tube, 1000mm, outside diameter 3.0mm, inside diameter 1.2mm, wall thickness 0.9mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%
Copper, rod, 500mm, diameter 9.5mm, hard, 99.9%
Copper, tube, 1000mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 1.2mm, inside diameter 0.56mm, wall thickness 0.32mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 16mm, as drawn, 99.99+%
Copper, sphere, 100pcs, diameter 1.0mm, precision sphere grade 200
Copper, tube, 1000mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 1.5mm, inside diameter 0.6mm, wall thickness 0.45mm, as drawn, 99.9%
Copper, wire reel, 50m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 25m, diameter 1.0mm, annealed, 99.9%
Copper, wire reel, 2000m, diameter 0.25mm, annealed, 99.9%
Copper, wire reel, 50m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.01mm, hard, 99.99%
Copper, wire reel, 100m, diameter 0.02mm, annealed, 99.99%
Copper, wire reel, 20m, diameter 0.25mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.025mm, as drawn, 99.99+%
Copper, wire reel, 1000m, diameter 0.04mm, annealed, 99.9%
Copper, wire reel, 50m, diameter 0.125mm, as drawn, 99.99+%
Copper, wire reel, 2m, diameter 0.125mm, as drawn, 99.99+%
Copper, wire reel, 200m, diameter 0.5mm, as drawn, 99.98+%
Copper, wire reel, 1m, diameter 0.125mm, as drawn, 99.99+%