- Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
Steroids (2007-09-22)
Vânia M A Moreira, Tadas S Vasaitis, Vincent C O Njar, Jorge A R Salvador
PMID17884122
ABSTRACT
A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17alpha-hydroxylase-C(17,20)-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.