- Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.
Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.
Bioorganic & medicinal chemistry letters (2009-02-17)
John Porter, Andrew Payne, Ian Whitcombe, Ben de Candole, Daniel Ford, Rachel Garlish, Adam Hold, Brian Hutchinson, Graham Trevitt, James Turner, Chloe Edwards, Clare Watkins, Jeremy Davis, Colin Stubberfield
PMID19217289
ABSTRACT
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.
MATERIALS