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325M-1

Sigma-Aldrich

CA-125 (OC125) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

OC125, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (325M-14)
vial of 0.5 mL concentrate (325M-15)
bottle of 1.0 mL predilute (325M-17)
vial of 1.0 mL concentrate (325M-16)
bottle of 7.0 mL predilute (325M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

ovarian carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... MUC16(94025)

General description

CA-125 (cancer antigen 125) is a large transmembrane glycoprotein belonging to the mucin family, encoded by the gene MUC16. By immunohistochemistry, CA-125 expression is not identified in normal ovarian tissue, but it is found in the normal cervix, fallopian tube, and endometrium. Positive immunostaining for CA-125 is seen in most ovarian carcinomas and epithelioid mesotheliomas.
Anti-CA-125 antibody reacts with epithelioid malignancies of the ovary, papillary serous carcinoma of the cervix, adenocarcinoma of the endometrium, clear cell adenocarcinoma of the bladder, and epithelioid mesothelioma. The antigen is formalin resistant, permitting the detection of ovarian cancer by immunohistochemistry, although serum assays for this protein are widely used to monitor ovarian cancer. Anti-CA-125 also reacts with antigens in seminal vesicle carcinoma.

Quality


IVD
IVD
IVD
RUO

Linkage

CA-125 Positive Control Slides, Product No. 325S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J G Quirk et al.
American journal of obstetrics and gynecology, 159(3), 644-649 (1988-09-01)
CA 125 was assayed in amniotic fluid and tissue extracts by immunoradiometric assay, and immunohistochemical studies were performed on paraffin-embedded sections of endometrium, decidua, and fetal membranes with the monoclonal antibody OC 125 used as primary antibody. The concentration of
I Fukazawa et al.
Archives of gynecology and obstetrics, 243(1), 41-50 (1988-01-01)
We studied immunohistochemical stains for TPA and CA125 in patients with benign and malignant gynecologic diseases. The results were as follows: (1) CA125 was not found in ovarian mucinous cystadenocarcinoma but was demonstrated immunohistochemically in 82% of ovarian serous cystadenocarcinomas
C Zhou et al.
The American journal of surgical pathology, 22(1), 113-120 (1998-01-09)
The clinical and pathologic features of 17 cases of papillary serous adenocarcinoma of the cervix (PSCC) were studied in women who ranged in age from 26 to 70 years. There was a bimodal age distribution, with one peak occurring before
I Mylonas et al.
Anticancer research, 23(2A), 1075-1080 (2003-06-25)
The aim of this study was to determine the tissue distribution of CA-125 in normal, hyperplastic and malignant endometrium. Endometrial tissue was obtained from women in proliferative (n = 5), early secretory (ES; n = 4) and late secretory (LS;
S E Kabawat et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 2(3), 275-285 (1983-01-01)
OC125, a murine monoclonal antibody, recognizes an antigenic determinant (CA125) that is associated with greater than 80% of epithelial ovarian neoplasms of serous, endometrioid, clear cell, and undifferentiated types. In the present report, a sensitive biotin-avidin immunoperoxidase technique was used
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