420355

Isoproterenol, Hydrochloride

Phenethylamine derivative.

• Synonym(s): Isoproterenol, Hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₇NO₃ · xHCl
• CAS Number: 51-30-9
• Molecular Weight: 211.26 (free base basis)
• MDL number: MFCD00012603
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥99% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white; white
• solubility: ethanol: soluble; water: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
• InChI key: IROWCYIEJAOFOW-UHFFFAOYSA-N

Description

General description

Phenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.

Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.

Biochem/physiol Actions

Cell permeable: no

Primary Target
β-adrenergic agonist

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997. Prostate 33, 46.
Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.
Yashiro, K., et al. 1994. J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.
von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable