14-522-M

ABL (T315I) Protein, active

recombinant, expressed in baculovirus infected Sf21 cells

• UNSPSC Code: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

Properties

• product name: Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
• biological source: human
• recombinant: expressed in baculovirus infected Sf21 cells
• mol wt: M_w 121 kDa
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (kinase)
• NCBI accession no.: NM_005157.3; NM_007313.2
• UniProt accession no.: P00519

Description

General description

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

Application

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

Biochem/physiol Actions

Protein Target: Abl

Target Sub-Family: TK

Packaging

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

Quality

routinely evaluated by phosphorylation of Abltide

Physical form

Ni²⁺/NTA-agarose

Storage and Stability

6 months at -70°C

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.