- In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.
In situ "click" assembly of small molecule matrix metalloprotease inhibitors containing zinc-chelating groups.
Organic letters (2008-12-05)
Mingyu Hu, Junqi Li, Shao Q Yao
PMID19053720
RESUMO
A panel of small molecule-based MMP inhibitors containing rhodanine warheads was assembled using "one-pot" click chemistry. Upon biological screening, moderate inhibitors were identified which specifically targets MMP-7 and MMP-13 over other MMPs.
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1-Azido-4-fluorobenzene solution, ~0.5 M in tert-butyl methyl ether, ≥95.0% (HPLC)