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  • Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP

Journal of inorganic biochemistry (2017-01-29)
Zrinka Rajic, Artak Tovmasyan, Otávio L de Santana, Isabelle N Peixoto, Ivan Spasojevic, Silmar A do Monte, Elizete Ventura, Júlio S Rebouças, Ines Batinic-Haberle
RESUMO

We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP

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Sigma-Aldrich
6-Bromo-1-hexanol, 97%
Sigma-Aldrich
p-Toluenesulfonyl chloride, reagent grade, ≥98%