Pular para o conteúdo
Merck

[Comparison of different G-CSF treatment effectiveness in experiments on irradiated mice].

Radiatsionnaia biologiia, radioecologiia (2012-12-12)
L M Rozhdestvenskiĭ, R A Shchegoleva, Iu B Deshevoĭ, N I Lisina, B A Titov
RESUMO

In the experiments on F1 (CBA x C57BL) and BALB mice irradiated by 137Cs gamma-rays, preparations of unglycosilated G-SCF such as Neupogen and their domestic analogs Leucostim and Neupomax were investigated. The tests such as 9-day bone marrow cellularity (BMC) and endogenous CFUs, the neutrophile number restoration, the 30-day survival index have shown that all three preparations have an approximately equal effectiveness relating to acute radiation disease treatment and granulopoiesis stimulation after a 5-10 day consecutive administration following irradiation of mice at lethal and sublethal doses. We have come to the conclusion that Leucostim and Neupomax can be regarded as adequate substitutes for Neupogen.

MATERIAIS
Número do produto
Marca
Descrição do produto

Filgrastim, European Pharmacopoeia (EP) Reference Standard