- N-Heterocyclic carbene-catalyzed monoacylation of 1,4-naphthoquinones with aldehydes.
N-Heterocyclic carbene-catalyzed monoacylation of 1,4-naphthoquinones with aldehydes.
The Journal of organic chemistry (2009-11-27)
María Teresa Molina, Cristina Navarro, Ana Moreno, Aurelio G Csákÿ
PMID19938843
RESUMO
The NHC-catalyzed conjugate hydroacylation of 1,4-naphthoquinones allows for the synthesis of monoacylated 1,4-dihydroxynaphthalene derivatives. These targets, difficult to prepare selectively by standard protocols, represent important intermediates in the elaboration of highly substituted 1,4-naphthoquinone derivatives, which constitute relevant pharmaceutical scaffolds. High regioselectivity has been observed in the hydroacylation reaction when starting from nonsymmetrical quinones.
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