UC126

4-Hydroxymephenytoin

• Sinônimo(s): (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione
• Fórmula empírica (Notação de Hill): C₁₂H₁₄N₂O₃
• Número CAS: 61837-65-8
• Peso molecular: 234.25
• Número MDL: MFCD00142316
• Código UNSPSC: 12161501
• ID de substância PubChem: 24724640
• NACRES: NA.77

Propriedades

• forma: solid
• cor: white
• pf: 153-154 °C
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
• InChI: 1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
• chave InChI: OQPLORUDZLXXPD-UHFFFAOYSA-N

Descrição

Descrição geral

CYP2C19 metabolite of mephenytoin.

Aplicação

4-Hydroxymephenytoin has been used for developing ultra performance LC (UPLC)- tandem mass spectrometry (MS/MS) assays for evaluating cytochrome P450 (CYP) probe drugs and their relevant metabolites in human urine or plasma samples. 4-hydroxymephenytoin has also been used for developing sub-2-micron particle LC/MS/MS-based methods for analyzing CYP450 probe substrate metabolites.

Ações bioquímicas/fisiológicas

4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)