SRP6007
NT-3 from mouse
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Sinônimo(s):
HDNF, NGF-2, NT-3, Nerve growth factor-2, Neurotrophic factor
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Produtos recomendados
fonte biológica
mouse
recombinante
expressed in E. coli
Ensaio
≥97% (HPLC)
≥97% (SDS-PAGE)
forma
lyophilized
peso molecular
13.6 kDa
embalagem
pkg of 10 μg
Impurezas
Endotoxin, tested
nº de adesão NCBI
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
mouse ... NTF3(18205)
Categorias relacionadas
Descrição geral
NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Aplicação
NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples.
Ações bioquímicas/fisiológicas
Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis.
forma física
Sterile filtered and lyophilized powder
Reconstituição
Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA et al
Journal of Neuroscience Methods, 282, 34-42 (2017)
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Ernfors P et al
Neuron, 14(6), 1153-1164 (1995)
Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.
Yoshida M et al
The Journal of Neuroscience, 31(35), 12663-12673 (2011)
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
Fari?as I et al
Nature, 369(6482), 658-661 (1994)
Shyan-Yuan Kao et al.
Bone, 145, 115837-115837 (2021-01-02)
The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG
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