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Key Documents

SRP4869

Sigma-Aldrich

Placental Lactogen human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinônimo(s):

CSA, CSH1, CSH2, CSMT, FLJ75407, PL

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About This Item

Número MDL:
Código UNSPSC:
51111800
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥95% (HPLC)
≥95% (SDS-PAGE)

forma

lyophilized

peso molecular

~22.3 kDa

embalagem

pkg of 20 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

cell based assay: suitable

Impurezas

endotoxin, tested

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... CSH1(1442)

Descrição geral

Human placental lactogen (HPL), also called human chorionic somatomammotropin 1, is a polypeptide placental hormone. Its structure and function is similar to that of growth hormone. The gene encoding this protein is localized on human chromosome 17. Recombinant human placental lactogen is a 22.3kDa protein.

Ações bioquímicas/fisiológicas

Human placental lactogen (HPL) modifies the metabolic state of the mother during pregnancy to facilitate the energy supply, glucose supply and growth of the fetus. Studies show that targeted expression of this protein in transgenic mice lead to an increase in proliferation of β-cells.

forma física

Sterile filtered and lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Certificados de análise (COA)

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Placental lactogen is expressed but is not translated into protein in breast cancer.
Tuttle TR
PLoS ONE, 9(1), e87325-e87325 (2014)
Meltem Muftuoglu et al.
Nucleic acids research, 34(1), 295-304 (2006-01-18)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, severe neurological abnormalities and prageroid symptoms. The CS complementation group B (CSB) protein is involved in UV-induced transcription coupled repair (TCR), base excision repair and general
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Freathy RM
Journal of Negative Results in Biomedicine, 5, 18-18 (2006)
Zinuo Chen et al.
Cell & bioscience, 11(1), 45-45 (2021-03-01)
In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using a high-throughput screen targeting the SARS-CoV-2
Marco F Lombardo et al.
Islets, 3(5), 250-258 (2011-07-19)
The search for factors either promoting islets proliferation or survival during adult life is a major issue for both type 1 and 2 diabetes mellitus. Among factors with mitogenic activity on pancreatic β-cells, human placental lactogen (hPL) showed stronger activity

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