SRP3064
IGF-Binding Protein 4 human
recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinônimo(s):
HT29-IGF-BP, IBP-4, colon cancer cell growth inhibitor
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About This Item
Código UNSPSC:
51111800
NACRES:
NA.32
Produtos recomendados
fonte biológica
human
recombinante
expressed in (BTI-Tn-5B1-4) High-5 Insect Cells
Ensaio
≥98% (HPLC)
≥98% (SDS-PAGE)
forma
lyophilized
peso molecular
25.8 kDa
embalagem
pkg of 20 μg
técnica(s)
cell culture | mammalian: suitable
Impurezas
<0.1 EU/μg endotoxin, tested
cor
white to off-white
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... IGFBP4(3487)
Descrição geral
The gene IGFBP4 (insulin-like growth factor-binding protein 4) is mapped to human chromosome 17q21. It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities. IGFBP4 can be cleaved by PAPP-A (pregnancy-associated plasma protein-A) in IGF-dependent mechanism.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Aplicação
IGF-Binding Protein 4 human has been used to check the dependency of FSH (follicle-stimulating hormone) action in human Cumulus granulosa cells on IGF-2 (insulin-like growth factor 2).
Ações bioquímicas/fisiológicas
IGFBP4 (insulin-like growth factor-binding protein 4) suppresses cell proliferation and DNA synthesis and induces cell death. IGFBP4 participates in adipose tissue expandability and interacts with IGF1 (insulin-like growth factor 1). Interaction with IGF1 disrupts mitogenic signaling. IGFBP4 is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients. IGFBP4 is also linked with cardiovascular death in type 1 diabetes patients in the absence/presence of nephropathy. It is also linked with the progression of tumors.
Sequência
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
forma física
Lyophilized from 1x PBS, pH 7.2.
Reconstituição
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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A J Ryan et al.
British journal of cancer, 101(2), 278-286 (2009-06-19)
Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1. Expression of IGF pathway components
IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy.
Hjortebjerg R, et al.
The Journal of Clinical Endocrinology and Metabolism, 100, 3032-3032 (2015)
Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
Li W, et al.
Cell Biology International, 41, 384-384 (2017)
Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
Gealekman O, et al.
The Journal of Biological Chemistry, 289, 18327-18327 (2014)
Tianfu Wu et al.
PloS one, 11(3), e0151491-e0151491 (2016-03-29)
Kidney biopsy remains the mainstay of Lupus Nephritis (LN) diagnosis and prognostication. The objective of this study is to identify non-invasive biomarkers that closely parallel renal pathology in LN. Previous reports have demonstrated that serum Insulin-like growth factor binding protein
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