SML3742

GK13S

≥98% (HPLC)

• Sinônimo(s): (S)-1-Cyano-N-(1-(4-(pent-4-yn-1ylcarbamoyl)phenyl)-1H-imidazol-4-yl)pyrrolidine-3-carboxamide
• Fórmula empírica (Notação de Hill): C₂₁H₂₂N₆O₂
• Peso molecular: 390.44
• Número MDL: MFCD35067861
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: -10 to -25°C

Descrição

Ações bioquímicas/fisiológicas

Cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1; chemogenomic probe suitable for the cellular study of UCHL1.


GK13S is a cell penetrant, potent and non-toxic activity-based probe for deubiquitinase UCHL1. GK13S, but not GK16S, led to the reduction of monoubiquitin levels in the human glioblastoma cell line U-87 MG. GK13S together with GK16S comprises a set of chemogenomic probes for UCHL1, which is suitable for investigation of cellular functions of UCHL. GK13S also binds to PARK7, C21orf33, ISOC1 andNIT2.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable