SML0603

Lixivaptan

≥96% (HPLC)

• Sinônimo(s): N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985
• Fórmula empírica (Notação de Hill): C₂₇H₂₁ClFN₃O₂
• Número CAS: 168079-32-1
• Peso molecular: 473.93
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• descrição: 4% w/w in ethyl acetate
• Nível de qualidade: 100
• Ensaio: ≥96% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 20 mg/mL, clear
• temperatura de armazenamento: room temp
• InChI: 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
• chave InChI: PPHTXRNHTVLQED-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable