SML0213

MC2050 hydrate

≥98% (HPLC)

• Sinônimo(s): 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• Fórmula empírica (Notação de Hill): C₁₉H₂₁N₅OS·2HCl · xH₂O
• Peso molecular: 440.39 (anhydrous basis)
• Número MDL: MFCD21608523
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825234
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: H₂O: ≥5 mg/mL at warmed to 60 °C
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• chave InChI: LMZZPRHHBPFDGE-UHFFFAOYSA-N

Descrição

Aplicação

MC2050 hydrate may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

Características e benefícios

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable