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Documentos

SCP0091

Sigma-Aldrich

Caspase 9 Substrate, chromogenic

≥95% (HPLC), lyophilized

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About This Item

Fórmula empírica (Notação de Hill):
C29H38N8O11
Peso molecular:
674.66
Código UNSPSC:
12352202
NACRES:
NA.32

product name

Caspase 9 Substrate, chromogenic, ≥95% (HPLC)

Ensaio

≥95% (HPLC)

forma

lyophilized

composição

Peptide Content, ≥75%

condição de armazenamento

protect from light

temperatura de armazenamento

−20°C

Amino Acid Sequence

Ac-Leu-Glu-His-Asp-pNA

Aplicação

Caspase 9 is an initiator caspase that cleaves procaspase 3 and procaspase 7 to propagate the apoptotic cascade. Caspase 9 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEHD peptide core such as the chromogenic substrate Ac-LEHD-pNa (Ac-Leu-Glu-His-Asp-p-nitroanalide).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Yinyuan Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27(5), 539-546 (2011-06-22)
Oxidative stress is known to be involved in a variety of pathological processes including atherosclerosis, diabetes, and neurodegenerative diseases. Understanding how intracellular signaling pathways respond to oxidative stress will have a significant implication in the therapy of these diseases. In
Lin-Li Zhou et al.
European journal of pharmacology, 670(2-3), 399-408 (2011-09-29)
Psoriasis is a chronic inflammatory skin disease affecting 1-3% of the world's population. Traditional Chinese medicines have been extensively used for treating psoriasis with promising clinical results. Celastrol, a triterpenoid isolated from a Chinese herb Celastrus orbiculatus caulis, has been
Juan Liu et al.
Molecular cancer, 10, 95-95 (2011-08-02)
Caspase-8 is a key upstream mediator in death receptor-mediated apoptosis and also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid. However, the role of caspase-8 in p53- and p73-dependent apoptosis induced by genotoxic drugs remains unclear. We recently reported
Aza-derivatives of resveratrol are potent macrophage migration inhibitory factor inhibitors.
Fujita, Y., et al.
Investigational New Drugs (2011)

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