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Key Documents

SAB4501763

Sigma-Aldrich

Anti-HSL antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Hormone sensitive lipase, LIPE, LIPS

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.43

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 116 kDa

reatividade de espécies

mouse, rat, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... LIPE(3991)

Categorias relacionadas

Descrição geral

Anti-HSL Antibody detects endogenous levels of total HSL protein.
Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. It is an intracellular lipase which acts on triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. It is mapped to human chromosome 19q13.

Imunogênio

The antiserum was produced against synthesized peptide derived from human HSL.

Immunogen Range: 518-567

Aplicação

Anti-HSL antibody has been used in SDS-PAGE and western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Ações bioquímicas/fisiológicas

Hormone sensitive lipase (HSL) plays an important role in lipolysis. Lack of HSL results in histologic abnormalities in white adipose tissue and an increase in macrophage infiltration.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Siwen Yang et al.
Molecules (Basel, Switzerland), 24(1) (2018-12-26)
Despite the edible fungus Amillariella mellea possessing a variety of biological activities, its effects on diabetes are still unclear. Polysaccharides are the main bioactive ingredients. In order to destroy the cell wall to obtain more polysaccharides, we used NaOH solution
Upregulation of Pnpla2 and Abhd5 and downregulation of G0s2 gene expression in mesenteric white adipose tissue as a potential reason for elevated concentration of circulating NEFA after removal of retroperitoneal, epididymal, and inguinal adipose tissue.
Dettlaff-Pokora A, et al.
Molecular and Cellular Biochemistry, 422(1-2), 21-29 (2016)
Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis
Stelmanska E, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 147, 31-39 (2015)
Identification of microdeletions spanning the Diamond-Blackfan anemia locus on 19q13 and evidence for genetic heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63(5), 1388-1395 (1998)
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes
Albert JS, et al.
The New England Journal of Medicine, 370(24), 2307-2315 (2014)

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