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Key Documents

SAB4501395

Sigma-Aldrich

Anti-Acetyl-CoA Carboxylase, N-Terminal antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

ACAC, ACACA, ACC-α, ACCA, Acetyl-CoA carboxylase 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 265 kDa

reatividade de espécies

mouse, rat, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

Q13085

nº de adesão UniProt

Q13085

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ACACA(31)

Categorias relacionadas

Descrição geral

Anti-Acetyl-CoA Carboxylase Antibody detects endogenous levels of total Acetyl-CoA Carboxylase protein.
Acetyl-CoA carboxylase 1 (ACC1) is a cytosolic enzyme. It is located on human chromosome 17q12.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Acetyl-CoA Carboxylase.

Immunogen Range: 46-95

Ações bioquímicas/fisiológicas

Acetyl-CoA carboxylase 1 (ACC1) catalyzes the rate-limiting step in de novo fatty acid biosynthesis. Acetyl-CoA is carboxylated to malonyl-CoA with the help of acetyl-CoA carboxylase (ACACA) in the fatty acid synthesis pathway. ACC1 is essential for the assembly of invadopodia.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl2
Damiano F, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(4), 388-398 (2018)
Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis
Scott K E N, et al.
PLoS ONE, 7(1), e29761-e29761 (2012)
Pietro Palumbo et al.
Gene, 538(2), 373-378 (2014-02-04)
Microdeletions of 17q12 including the hepatocyte nuclear factor 1 beta (HNF1B) gene, as well as point mutations of this gene, are associated with the Renal Cysts and Diabetes syndrome (RCAD, OMIM 137920) and genitourinary alterations. Also, microdeletions encompassing HNF1B were
Bruna Corominas-Faja et al.
Oncotarget, 5(18), 8306-8316 (2014-09-24)
Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of

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