K0253
Keratin from human epidermis
aqueous solution
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About This Item
fonte biológica
human epidermis
Ensaio
≥90% (SDS-PAGE)
forma
urea solution
técnica(s)
ELISA: suitable
nº de adesão UniProt
temperatura de armazenamento
2-8°C
Informações sobre genes
human ... KRT1(3848)
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Descrição geral
Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13. It is the primary component of hair, skin and nails.
Aplicação
Keratin from human epidermis has been used:
- as an analyte and a cross-reactant in the antibody-immobilized chip for testing selectivity coefficients
- as a standard in extracellular matrix (ECM) protein in in vitro protein degradation assays.
- asa a standard in enzyme linked immunosorbent assay (ELISA)
Ações bioquímicas/fisiológicas
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.
forma física
Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Skin Sens. 1
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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The Journal of cell biology, 201(5), 681-692 (2013-05-22)
Maintenance of epithelial cell adhesion is crucial for epidermal morphogenesis and homeostasis and relies predominantly on the interaction of keratins with desmosomes. Although the importance of desmosomes to epidermal coherence and keratin organization is well established, the significance of keratins
Keratin-based Biomaterials and Bioproducts, 5-5 (2017)
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Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage
Jackson AS, et al.
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Anticancer research, 33(6), 2415-2424 (2013-06-12)
The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh overexpression was associated with poor prognosis. Therefore, we analyzed the effect of Hh signaling blockade with
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