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H6503

Sigma-Aldrich

L-Homocysteine thiolactone hydrochloride

≥98% (TLC)

Sinônimo(s):

L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C4H7NOS · HCl
Número CAS:
31828-68-9
Peso molecular:
153.63
Beilstein:
3911455
Número CE:
250-824-1
Número MDL:
MFCD00065494
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de substância PubChem:
24895745
NACRES:
NA.26

product name

L-Homocysteine thiolactone hydrochloride, ≥98% (TLC)

Nível de qualidade

200

Ensaio

≥98% (TLC)

forma

powder

cor

white

pf

185 °C

aplicação(ões)

detection
peptide synthesis

cadeia de caracteres SMILES

Cl[H].N[C@H]1CCSC1=O

InChI

1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

chave InChI

ZSEGSUBKDDEALH-DFWYDOINSA-N

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Aplicação


  • Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: This investigation demonstrates the effects of DL-homocysteine thiolactone on heart function, offering insights into its use in cardiovascular research and potential therapeutic applications (Zivkovic et al., 2013).

  • Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease: The study explores how L-homocysteine thiolactone could affect platelet responses in therapy for coronary artery diseases, pointing to its importance in cardiovascular therapeutics (Karolczak et al., 2013).

Ações bioquímicas/fisiológicas

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Derrick L Sauls et al.
Thrombosis research, 127(6), 576-581 (2011-02-15)
We have shown that homocysteinemic rabbits have altered fibrinogen that forms fibrin clots with increased resistance to fibrinolysis. Homocysteine thiolactone is a metabolite of homocysteine (Hcys) that can react with amines and introduce a new sulfhydryl group into proteins. Recent
A Rašić-Marković et al.
Acta physiologica Hungarica, 98(1), 17-26 (2011-03-11)
The aim of our study was to investigate the effects of ifenprodil and MK-801 on D,L-homocysteine thiolactone induced seizures in adult rats.Male Wistar rats were divided into following groups: 1. Saline-treated (C, n=10); 2. D,L-homocysteine thiolactone 8 mmol/kg, i.p. (H
Han-Hsin Chang et al.
Molecular vision, 17, 1946-1956 (2011-08-19)
Hyperhomocysteinemia is known to cause degeneration of retinal ganglion cells, but its influence on photoreceptors remains largely unknown. In particular, the role of homocysteine-thiolactone (Hcy-T)--the physiologic metabolite of homocysteine that has been proven to be more cytotoxic than homocysteine itself--as
Hieronim Jakubowski
Acta biochimica Polonica, 58(2), 149-163 (2011-06-07)
All living organisms conduct protein synthesis with a high degree of accuracy maintained in the transmission and flow of information from a gene to protein product. One crucial 'quality control' point in maintaining a high level of accuracy is the
Joanna Malinowska et al.
Platelets, 23(5), 409-412 (2011-10-21)
Homocysteine (Hcys) and homocysteine thiolactone (HTL) concentrations in organism are correlated with a number of serious pathologies. In the literature, there are few papers describing studies on the effects of homocysteine on proteins that participate in blood coagulation and fibrinolysis
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