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D6539

Sigma-Aldrich

2-Deoxy-α-D-ribose 1-phosphate bis(cyclohexylammonium) salt

≥97% (TLC)

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About This Item

Fórmula empírica (Notação de Hill):
C5H11O7P · 2C6H13N
Número CAS:
102783-28-8
Peso molecular:
412.46
Beilstein:
3785872
Número MDL:
MFCD00056072
Código UNSPSC:
12352201
ID de substância PubChem:
329798830
NACRES:
NA.25

fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥97% (TLC)

Formulário

powder

cor

white

solubilidade

water: 50 g/L at 20 °C

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NC1CCCCC1.NC2CCCCC2.OC[C@H]3O[C@@H](C[C@@H]3O)OP(O)(O)=O

InChI

1S/2C6H13N.C5H11O7P/c2*7-6-4-2-1-3-5-6;6-2-4-3(7)1-5(11-4)12-13(8,9)10/h2*6H,1-5,7H2;3-7H,1-2H2,(H2,8,9,10)/t;;3-,4+,5+/m..0/s1

chave InChI

GVYUZZDUVZHJAM-CGKAESPRSA-N

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Aplicação

2-Deoxyribose 1-phosphate (2dR1P) may be used in pyrimidine metabolism research to identify and characterize thymidine phosphorylase(s)/platelet-derived endothelial cell growth factor(s)(PD-ECGF)/gliostatin(s). 2-Deoxyribose 1-phosphate may be used to study processes such as angiogenesis in tumor cells at the level of thymidine phosphorylase activity. 2-Deoxy-a-D-ribose 1-phosphate (dR-1-P) is used in the organic synthesis of 2′-deoxynucleosides such as cladribine.

Nota de preparo

Enzymatically prepared

Outras notas

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLBS2990V
SLBC4042V
060M5001V
060M5001
028K5000

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Candida Deves et al.
Molecular bioSystems, 10(3), 592-604 (2014-01-11)
Human Thymidine Phosphorylase (HTP), also known as the platelet-derived endothelial cell growth factor (PD-ECGF) or gliostatin, catalyzes the reversible phosphorolysis of thymidine (dThd) to thymine and 2-deoxy-α-d-ribose-1-phosphate (2dR1P). HTP is a key enzyme in the pyrimidine salvage pathway involved in
Dina S Vara et al.
Thrombosis and haemostasis, 109(6), 1108-1119 (2013-03-16)
Using direct injection mass spectrometry (DIMS) we discovered that deoxyribose-1-phosphate (dRP) is released by platelets upon activation. Interestingly, the addition of exogenous dRP to human platelets significantly increased platelet aggregation and integrin αIIbβ3 activation in response to thrombin. In parallel
Hironori Komatsu et al.
Nucleosides, nucleotides & nucleic acids, 24(5-7), 1127-1130 (2005-10-27)
Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
Shin-ichi Akiyama et al.
Cancer science, 95(11), 851-857 (2004-11-18)
Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TP is overexpressed in various tumors and plays an important role in angiogenesis, tumor growth, invasion and metastasis. The

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