D4505

5,5-Diphenylhydantoin sodium salt

≥99%

• Sinônimo(s): 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Fórmula linear: C₁₅H₁₁N₂O₂Na
• Número CAS: 630-93-3
• Peso molecular: 274.25
• Número CE: 211-148-2
• Número MDL: MFCD00069674
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277707
• NACRES: NA.77

Propriedades

• Ensaio: ≥99%
• forma: powder
• solubilidade: aqueous base: soluble
• cadeia de caracteres SMILES: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• chave InChI: FJPYVLNWWICYDW-UHFFFAOYSA-M
• Informações sobre genes: human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

Descrição

Descrição geral

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

Aplicação

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds
• in seizure behavior testing as an anticonvulsant in Drosophila
• in in vivo embryo toxicity test in mouse embryonic stem cells

Ações bioquímicas/fisiológicas

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H317,H361
• Declarações de precaução: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges