C1353
Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinônimo(s):
Anti-APCA, Anti-BI, Anti-CACNL1A4, Anti-CAV2.1, Anti-DEE42, Anti-EA2, Anti-EIEE42, Anti-FHM, Anti-HPCA, Anti-MHP1, Anti-SCA6
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About This Item
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
lyophilized powder
peso molecular
antigen (major) 190 kDa
antigen (minor) 210 kDa
reatividade de espécies
rat, mouse
técnica(s)
immunohistochemistry: 1:100
western blot: 1:200
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Cacna1a(12286)
rat ... Cacna1a(25398)
Imunogênio
synthetic peptide corresponding to amino acids 865-881 of the α1A subunit of rat brain voltage-gated calcium channel (VGCC, CNA1) (with additional N-terminal lysine and tyrosine) conjugated to KLH.
Aplicação
Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 and western blotting at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)
Immunoprecipitation (1 paper)
Ações bioquímicas/fisiológicas
The Cav2.1 P/Q voltage-dependent calcium channel is encoded by the CACNA1A gene in humans. It is a pore-forming essential subunit embedded in the plasma membrane. Mutation in this gene causes a number of human neurologic diseases including familial hemiplegic migraine. CACNA1A is associated with both hemiplegic migraine and migraine with aura in patients. Mutation in this gene is the cause of Type 2 episodic ataxia (EA2) the most common subtype among a group of rare hereditary syndromes characterized by recurrent attacks of ataxia.
forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
T Sakurai et al.
The Journal of biological chemistry, 270(36), 21234-21242 (1995-09-08)
Biochemical properties of the alpha 1 subunits of class A brain calcium channels (alpha 1A) were examined in adult rat brain membrane fractions using a site-directed anti-peptide antibody (anti-CNA3) specific for alpha 1A. Anti-CNA3 specifically immunoprecipitated high affinity receptor sites
Steven B Condliffe et al.
The Journal of biological chemistry, 288(47), 33873-33883 (2013-10-11)
Mutations in the CACNA1A gene, which encodes the pore-forming α1A subunit of the CaV2.1 voltage-gated calcium channel, cause a number of human neurologic diseases including familial hemiplegic migraine. We have analyzed the functional impact of the E1015K amino acid substitution
Xue Liu et al.
The Journal of physiology, 591(13), 3309-3324 (2013-04-25)
Horizontal cells send inhibitory feedback to photoreceptors, helping form antagonistic receptive fields in the retina, but the neurotransmitter and the mechanisms underlying this signalling are not known. Since the proteins responsible for conventional Ca(2+)-dependent release of GABAergic synaptic vesicles are
Wei Chun Chen et al.
Hearing research, 278(1-2), 52-68 (2011-02-02)
As with other elements of the peripheral auditory system, spiral ganglion neurons display specializations that vary as a function of location along the tonotopic axis. Previous work has shown that voltage-gated K(+) channels and synaptic proteins show graded changes in
Yafang Hu et al.
PloS one, 8(2), e56362-e56362 (2013-02-27)
Type 2 episodic ataxia (EA2) is the most common subtype among a group of rare hereditary syndromes characterized by recurrent attacks of ataxia. More than 60 mutations and several gene rearrangements due to large deletions in CACNA1A gene have been
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