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AV44041

Sigma-Aldrich

Anti-SLC25A22 antibody produced in rabbit

IgG fraction of antiserum

Sinônimo(s):

Anti-FLJ13044, Anti-GC1, Anti-Solute carrier family 25 (mitochondrial carrier: glutamate), member 22

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

IgG fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

36 kDa

reatividade de espécies

human, mouse

concentração

0.5 mg - 1 mg/mL

técnica(s)

immunohistochemistry: suitable
western blot: suitable

nº de adesão NCBI

NP_078974

nº de adesão UniProt

Q9H936

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SLC25A22(79751)

Imunogênio

Synthetic peptide directed towards the N terminal region of human SLC25A22

Aplicação

Anti-SLC25A22 antibody produced in rabbit is suitable for western blotting at a concentration of 1.25μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Ações bioquímicas/fisiológicas

SLC25A22 (GC1) is a mitochondrial glutamate carrier that transport glutamine across the inner mitochondrial membrane. The transport of glutamate to the cytoplasm from mitochondria by SLC25A22 regulates the secretion of insulin secretory vesicles in the islet β-cells.

Sequência

Synthetic peptide located within the following region: LQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS

forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sumiyo Morita et al.
PeerJ, 1, e162-e162 (2013-10-11)
Insulin secretion from pancreatic β-cells plays an essential role in blood glucose homeostasis and type 2 diabetes. Many genes are involved in the secretion of insulin and most of these genes can be targeted by microRNAs (miRNAs). However, the role
Sudhir G Tattikota et al.
The Journal of biological chemistry, 290(33), 20284-20294 (2015-07-15)
In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however, the pathways governing this adaptive response are not entirely established. Although the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes
Giuseppe Fiermonte et al.
The Journal of biological chemistry, 277(22), 19289-19294 (2002-03-19)
The mitochondrial carriers are a family of transport proteins in the inner membranes of mitochondria. They shuttle substrates, metabolites, and cofactors through this membrane and connect cytoplasm functions with others in the matrix. Glutamate is co-transported with H(+) (or exchanged
Sudhir G Tattikota et al.
Cell metabolism, 19(1), 122-134 (2013-12-24)
Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in

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