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Documentos

PHR1207

Supelco

2-Butanona

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Etilmetilcetona, MEK, Metiletilcetona

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About This Item

Fórmula linear:
C2H5COCH3
Número CAS:
78-93-3
Peso molecular:
72.11
Beilstein:
741880
Número CE:
201-159-0
Número MDL:
MFCD00011648
Código UNSPSC:
41116107
ID de substância PubChem:
329823214
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

300

Agency

traceable to USP 1430101

densidade de vapor

2.49 (vs air)

pressão de vapor

71 mmHg ( 20 °C)

Certificado de análise (CofA)

current certificate can be downloaded

temperatura de autoignição

960 °F

Lim. expl.

10.1 %

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.379 (lit.)

pb

80 °C (lit.)

pf

−87 °C (lit.)

densidade

0.805 g/mL at 25 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

CC(CC)=O

InChI

1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3

chave InChI

ZWEHNKRNPOVVGH-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 2-Butanone (Methyl ethyl ketone, MEK), an aliphatic ketone, is considered as an aprotic and protophilic solvent. Its ability as an anticonvulsive agent in lithium-pilocarpine-induced status epilepticus in rats is reported.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC0146 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palavra indicadora

Danger

Frases de perigo

H225 - H319 - H336

Classificações de perigo

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Órgãos-alvo

Central nervous system

Perigos de suplementos

EUH066

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

30.2 °F - closed cup

Ponto de fulgor (°C)

-1 °C - closed cup

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
LRAC9786
LRAC0146
P500207
LRAB3828

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

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2-Butanone OmniSolv®

Supelco

BX1673

2-Butanone

2-Butanona suitable for HPLC, ≥99.7%

Sigma-Aldrich

34861

2-Butanona

Metil-terc-butil éter Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1560

Metil-terc-butil éter

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition (2012)
Yang Cao et al.
British journal of haematology, 168(5), 701-707 (2014-11-06)
CXCR4(WHIM) frameshift and nonsense mutations follow MYD88(L265P) as the most common somatic variants in Waldenström Macroglobulinaemia (WM), and impact clinical presentation and ibrutinib response. While the nonsense (CXCR4(S338X) ) mutation has been investigated, little is known about CXCR4 frameshift (CXCR4(FS)
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Nature communications, 6, 6431-6431 (2015-03-17)
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced
Inna V Fedorenko et al.
Proteomics, 15(2-3), 327-339 (2014-10-24)
Basal and kinase inhibitor driven adaptive signaling has been examined in a panel of melanoma cell lines using phosphoproteomics in conjunction with pathway analysis. A considerable divergence in the spectrum of tyrosine-phosphorylated peptides was noted at the cell line level.
L Schafranek et al.
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Kinase inhibitors block proliferative signals in BCR-ABL1+ leukemic cells, but their capacity to induce apoptosis is poorly understood. Initial studies suggested that very brief exposure to kinase inhibitors was sufficient to induce apoptosis in chronic myeloid leukemia (CML) cells. However
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