MABE1007

Anti-TEL-AML1 fusion Antibody, clone 6F2

• Sinônimo(s): TEL-AML1 fusion|ETV6-RUNX1|Transcription factor ETV6|ETS translocation variant 6|ETS-related protein Tel1|Tel|Runt-related transcription factor 1|Acute myeloid leukemia 1 protein|Core-binding factor subunit alpha-2|CBF-alpha-2|Oncogene AML-1|Polyomavirus
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rat
• Nível de qualidade: 300
• clone: monoclonal
• reatividade de espécies: human
• técnica(s): ChIP: suitable; flow cytometry: suitable; western blot: suitable

Descrição

Descrição geral

The chimeric transcription factor TEL-AML1 (ETV6-RUNX1) is the result of the reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration found in childhood B-cell precursor acute lymphoblastic leukaemia (ALL). The runt-homology DNA-binding domain of AML1 retained in the TEL-AML1 mediates the DNA-binding activity of the fusion protein. The fusion protein not only exhibits altered transcription activity, it also affects normal transcription activity by directly competing against wild-type AML1 for promoter binding, sequestering transcriptional cofactors available for the wild-type protein, as well as dimerizing with wild-type protein.

Imunogênio

KLH-conjugated linear peptide corresponding to human TEL-AML1 fusion.

Aplicação

Anti-TEL-AML1 fusion Antibody, clone 6F2 is an antibody against TEL-AML1 fusion for use in Western Blotting, Flow Cytometry, Chromatin Immunoprecipitation .

Flow Cytometry Analysis: A representative lot detected TEL-AML1 fusion induction upon mifepristone treatment in BA/F3 cells expressing inducible TEL-AML1 fusion (Linka, Y., et al. (2013). Blood Cancer J. 3:e151).
Chromatin Immunoprecipitation Analysis

Qualidade

Evaluated by Western Blotting in lysate from mifepristone-treated murine BA/F3 cells expressing inducible TEL-AML1 fusion.
Western Blotting Analysis: A 1:20,000 dilution of this antibody detected TEL-AML1 fusion induction in 2.5 ug lysate from mifepristone-treated murine BA/F3 cells expressing inducible TEL-AML1 fusion.

Outras notas

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