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MAB3448

Sigma-Aldrich

Anti-Heterochromatin Protein-1 β Antibody, clone 1MOD-1A9

ascites fluid, clone 1MOD-1A9, Chemicon®

Sinônimo(s):

HP1b

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

1MOD-1A9, monoclonal

reatividade de espécies

mouse, human

fabricante/nome comercial

Chemicon®

técnica(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

nº de adesão NCBI

NM_007622.3

nº de adesão UniProt

P83917

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CBX1(10951)

Descrição geral

Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated histones H3/H4 into nascent chromatin during DNA replication.

Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1α, HP1β and HP1γ). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated.

Especificidade

Reacts with Heterochromatin protein-1 b (HP1b).

Imunogênio

Recombinant mouse HP1beta.

Aplicação

Use Anti-Heterochromatin Protein-1 β Antibody, clone 1MOD-1A9 (Mouse Monoclonal Antibody) validated in ELISA, ICC, IHC, IP, WB to detect Heterochromatin Protein-1 β also known as HP1b.
Western blot: 1:500-1:5,000


Immunofluorescence: 1:500-1:5,000


Immunohistochemistry: 1:500-1:5,000


Immunoprecipitation: 1:500 - 1:5,000


ELISA: 1:500-1:5,000


Optimal working dilutions must be determined by the end user.

Descrição-alvo

28 kDa

Nota de análise

Control
HeLa, 293 or NIH/3T3 cell lysates

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote.
Aline V Probst, Fatima Santos, Wolf Reik, Genevieve Almouzni, Wendy Dean
Chromosoma null
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Yang, G; Rosen, DG; Zhang, Z; Bast, RC; Mills, GB; Colacino, JA; Mercado-Uribe, I; Liu, J
Proceedings of the National Academy of Sciences of the USA null
Epigenetic regulation of myogenic gene expression by heterochromatin protein 1 alpha.
Sdek, P; Oyama, K; Angelis, E; Chan, SS; Schenke-Layland, K; MacLellan, WR
Testing null
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.
Loh, YH; Zhang, W; Chen, X; George, J; Ng, HH
Genes & Development null
Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis.
Liu, YJ; Nakamura, T; Nakano, T
Biology of reproduction null
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