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ABN174

Sigma-Aldrich

Anti-MNX1 (HB9) Antibody

from rabbit, purified by affinity chromatography

Sinônimo(s):

Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

mouse, human

técnica(s)

immunohistochemistry: suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... MNX1(3110)

Descrição geral

Motor neuron and pancreas homeobox protein 1 (MNX1) is a transcription factor that is predominantly expressed in lymphoid and pancreatic tissues. It is involved in the development and function of the pancreas. Abnormal expression of MNX1 results in an autosomal dominant condition known as Currarino syndrome.

Especificidade

Other homologies: Zebrafish (94% sequence homology) and Xenopus (89% sequence homology).
This antibody recognizes a portion of the Homeobox DNA binding domain.

Imunogênio

KLH-conjugated linear peptide corresponding to human MNX1.

Aplicação

Anti-MNX1 (HB9) Antibody detects level of MNX1 (HB9) & has been published & validated for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected MNX1 in human pancreas and mouse cerebral cortex tissues.
Research Category
Neuroscience
Research Sub Category
Transcription Factors

Qualidade

Evaluated by Western Blot in PANC-1 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected MNX1 in 10 µg of PANC-1 cell lysate.

Descrição-alvo

~50 kDa observed. An uncharacterized band may appear at ~48 kDa in some lysates.

forma física

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
PANC-1 cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Gonzalo Perez-Siles et al.
Disease models & mechanisms, 13(2) (2020-01-24)
ATP7A encodes a copper-transporting P-type ATPase and is one of 23 genes in which mutations produce distal hereditary motor neuropathy (dHMN), a group of diseases characterized by length-dependent axonal degeneration of motor neurons. We have generated induced pluripotent stem cell
Toma Tebaldi et al.
Molecular cell, 71(2), 256-270 (2018-07-22)
The RNA-binding protein HuD promotes neurogenesis and favors recovery from peripheral axon injury. HuD interacts with many mRNAs, altering both stability and translation efficiency. We generated a nucleotide resolution map of the HuD RNA interactome in motor neuron-like cells, identifying

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