AB16951
Anti-STAT1-α Antibody
Chemicon®, from rabbit
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
mouse, human
fabricante/nome comercial
Chemicon®
técnica(s)
immunoprecipitation (IP): suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... STAT1(6772)
Especificidade
STAT′s (signal transducers and activators of transcripition) are a family of cytoplasmic latent transription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5, Stat5beta, and Stat6), Stat1, Stat3, Stat5alpha, and Stat5beta have a wide activation profile (Leonard et al. 1998; Schindler et al. 1995). STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN-beta, IFN-gamma, and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF and G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1) (Darnell 1997). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta, which are encoded by the same gene with splicing variant (Schindler et al. 1992).
Imunogênio
Polyclonal antibody raised against a peptide corresponding to amino acids 712-750 of human STAT1alpha (Schindler et al. 1992). The corresponding sequences of mouse differ from those of the immunogenic peptide by four amino acids.
Aplicação
Detect STAT1-α also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1-α Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western blot: 1:1000-1:2000
Immunoprecipitation: 2 to 4 μg
Whole cell lysate from HeLa , Jurkat, or A431 cells can be used as a positive control for Western Blot and a 91 kDa band can be detected. No reaction to the 84 kDa STAT1beta.
Optimal working dilutions must be determined by end user.
Immunoprecipitation: 2 to 4 μg
Whole cell lysate from HeLa , Jurkat, or A431 cells can be used as a positive control for Western Blot and a 91 kDa band can be detected. No reaction to the 84 kDa STAT1beta.
Optimal working dilutions must be determined by end user.
forma física
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Format: Purified
Armazenamento e estabilidade
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Descrição
Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
W J Leonard et al.
Annual review of immunology, 16, 293-322 (1998-05-23)
Cytokines and interferons are molecules that play central roles in the regulation of a wide array of cellular functions in the lympho-hematopoietic system. These factors stimulate proliferation, differentiation, and survival signals, as well as specialized functions in host resistance to
Diego E Montoya-Durango et al.
Mutation research, 665(1-2), 20-28 (2009-05-12)
Long interspersed nuclear elements (LINEs or L1 elements) are targeted for epigenetic silencing during early embryonic development and remain inactive in most cells and tissues. Here we show that E2F-Rb family complexes participate in L1 elements epigenetic regulation via nucleosomal
Kiyoshi Himmelsbach et al.
World journal of virology, 7(1), 10-20 (2018-02-23)
To identify cell culture models supportive for Zika virus (ZIKV) replication. Various human and non-human cell lines were infected with a defined amount of ZIKV Polynesia strain. Cells were analyzed 48 h post infection for the amount of intracellular and
J E Darnell
Science (New York, N.Y.), 277(5332), 1630-1635 (1997-09-12)
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site
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