14-440-M

PKA Protein, Recombinant, 10 µg

Recombinant human full length PKA, catalytic subunit type alpha, untagged, for use in Kinase Assays.

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

Propriedades

• fonte biológica: human
• Nível de qualidade: 100
• recombinante: expressed in E. coli; expressed in BL21 DE3 cells
• linha de produto: Upstate^®
• forma: liquid
• atividade específica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.); 8580 U/mg
• prazo de validade: 1 yr
• peso molecular: M_w 40.7 kDa
• purificado por: chromatography
• reatividade de espécies: human
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable (kinase)
• solubilidade: water: soluble
• nº de adesão: (FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus. ); NM_002730.3
• nº de adesão NCBI: NM_002730.3; NM_207518.1
• nº de adesão UniProt: P17612
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... PRKACA(46909581)

Descrição

Descrição geral

Research area: Cell Signaling

Product Source: Expressed in E.coli BL21 (DE3) pLysS cells Recombinant human full length PKA, catalytic subunit type alpha, untagged Protein kinase A (PKA) is a serine protein kinase and heterotetrameric holoenzyme that targets serine and threonine residues.

Recombinant human full length PKA, catalytic subunit type alpha, untagged

Ações bioquímicas/fisiológicas

Protein Target: PKA; Target Sub-Family: AGC. Protein kinases are vital for integrating signaling networks within eukaryotic cells. In Hedgehog-responsive cells, PKA is crucial for regulating proliferation and fate determination by influencing Hedgehog signaling transduction. PKA has numerous targets that are linked to adhesion or migration.

Embalagem

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-440M when ordering the 250 µg size.

Qualidade

routinely evaluated by phosphorylation of Kemptide substrate in vitro

Descrição-alvo

PKA

Ligação

Replaces: 14-114

forma física

Phosphocellulose P11 chromatography

Armazenamento e estabilidade

1 year at -70°C

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1