05-615

Anti-SUV39H1 Histone Methyltransferase antibody

UPSTATE^®, mouse monoclonal, MG44

• Sinônimo(s): KMT1A
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• Nome do produto: Anti-SUV39H1 Antibody, clone MG44, ascites fluid, clone MG44, Upstate^®
• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: ascites fluid
• tipo de produto de anticorpo: primary antibodies
• clone: MG44, monoclonal
• reatividade de espécies: mouse, human
• fabricante/nome comercial: Upstate^®
• técnica(s): ChIP: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotipo: IgG
• nº de adesão NCBI: NM_003173.2
• nº de adesão UniProt: O43463
• Condições de expedição: dry ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SUV39H1(6839)

Descrição

Descrição geral

Post -translational modification of histones, such as phosphorylation, acetylation, and methylation, are crucial for chromatin remodeling. SUV39H1 and Suv39h1 are the human and mouse homologs of Drosophila Su(var)3-9 protein, respectively. These proteins selectively methylate histone H3 at lysine 9 creating a high-affinity binding site for the HP1 proteins (heterochromatin protein 1). HP1 proteins are known to interact with transcription suppressor proteins, suggesting that the interactions with SUV39H1 and methylated histone H3 mediate a silence effect on the transcription of target genes. Furthermore, over-expression of SUV39H1 in HeLa cells causes a redistribution of endogenous HP1 proteins and growth retardation, suggesting that SUV39H1-mediated modulation of heterochromatin can impair cell cycle progression.

Especificidade

Recognizes SUV39H1.

Imunogênio

MBP fusion protein corresponding to residues 1-412 of human SUV39H1

Aplicação

Anti-SUV39H1 Antibody, clone MG44 is a Mouse Monoclonal Antibody for detection of SUV39H1 also known as KMT1A, Histone H3-K9 Methyltransferase 1 & has been validated in ChIP, IP & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

Chromatin Biology

Qualidade

routinely evaluated by immunoblot on U2OS cells lysed in RIPA with 0.1% SDS and sonicated

Descrição-alvo

50 kDa

Ligação

Replaces: MABE552

forma física

Protein G Purified immunoglobulin in Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Unpurified

Armazenamento e estabilidade

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Nota de análise

Control
U2OS cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1