D-906
Desipramine hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Fórmula empírica (Notação de Hill):
C18H23ClN2
Número CAS:
Peso molecular:
302.84
Código UNSPSC:
41116107
NACRES:
NA.24
Produtos recomendados
grau
certified reference material
forma
liquid
Características
Snap-N-Spike®/Snap-N-Shoot®
embalagem
ampule of 1 mL
fabricante/nome comercial
Cerilliant®
concentração
1.0 mg/mL in methanol (as free base)
técnica(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
aplicação(ões)
clinical testing
formato
single component solution
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
Cl.CNCCCN1c2ccccc2CCc3ccccc13
InChI
1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
chave InChI
XAEWZDYWZHIUCT-UHFFFAOYSA-N
Informações sobre genes
human ... SLC6A2(6530)
Descrição geral
A Certified Solution Standard suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing. Desipramine is a tricyclic antidepressant (TCA) sold under the brand names Norpramin® and Pertofrane. This TCA drug is also a primary active metabolite of imipramine.
Aplicação
- Pharmacological Treatments for Localized Provoked Vulvodynia: Reviews current pharmacological treatments, including tricyclic antidepressants like desipramine hydrochloride, emphasizing their role in managing chronic pain conditions, crucial for ongoing research in neuropharmacology and clinical practice (Bajzak et al., 2023).
- Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures: Highlights the use of desipramine hydrochloride in neurobiological research, specifically its effects on inflammatory responses in nerve injury models, underscoring its significance in neuropharmacological studies (Serafini et al., 2024).
- Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: Discusses the therapeutic potential of lipid emulsions in managing toxicity caused by drugs, including desipramine hydrochloride, which is essential for improving safety profiles in clinical settings (Hwang and Sohn, 2024).
- Sustainable beeswax modified cellulose paper for the determination of tricyclic antidepressants: Researches innovative methods for detecting tricyclic antidepressants like desipramine hydrochloride in biofluids, pivotal for advancing forensic and clinical toxicology (González-Bermúdez et al., 2024).
- Sleep-wake dependent hippocampal regulation of fear memory: Although indirectly related, this study forms part of the broader context of neurological research where desipramine hydrochloride could be used to modulate neurochemical pathways, relevant for understanding sleep-related memory processes (Wen et al., 2024).
Informações legais
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Norpramin is a registered trademark of Aventisub II Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
produto relacionado
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Órgãos-alvo
Eyes
Código de classe de armazenamento
3 - Flammable liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
49.5 °F - closed cup
Ponto de fulgor (°C)
9.7 °C - closed cup
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Richard M O'Connor et al.
Pharmacology, biochemistry, and behavior, 103(3), 561-567 (2012-10-13)
The neurotransmitter glutamate is increasingly being implicated as playing a role in the molecular pathology underlying depression. The group III family of metabotropic glutamate (mGlu) receptors (mGlu(4,) mGlu(7) and mGlu(8) receptors) remains the most poorly investigated of all glutamate receptors
Alain Watts et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(39), 13411-13420 (2012-09-28)
Rapid eye movement (REM) sleep enhances hippocampus-dependent associative memory, but REM deprivation has little impact on striatum-dependent procedural learning. Antidepressant medications are known to inhibit REM sleep, but it is not well understood if antidepressant treatments impact learning and memory.
O F O'Leary et al.
Neuroscience, 228, 36-46 (2012-10-17)
Approximately 50% of patients with a major depressive episode fail to achieve remission with first-line antidepressant treatments. Second-line treatment strategies for such patients include lithium augmentation of antidepressants, particularly with tricyclic antidepressants. The neurobiological mechanisms underlying the therapeutic effects of
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To determine the effect of increasing adult age on predicted metabolic drug clearance. Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®. Simulations were conducted using
Tara A LeGates et al.
Nature, 491(7425), 594-598 (2012-11-16)
The daily solar cycle allows organisms to synchronize their circadian rhythms and sleep-wake cycles to the correct temporal niche. Changes in day-length, shift-work, and transmeridian travel lead to mood alterations and cognitive function deficits. Sleep deprivation and circadian disruption underlie
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