D-055

N-Desethylamiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (Notação de Hill): C₂₃H₂₆ClI₂NO₃
• Número CAS: 96027-74-6
• Peso molecular: 653.72
• Número CE: 200-659-6
• Número MDL: MFCD08060094
• Código UNSPSC: 41116107
• ID de substância PubChem: 329798619
• NACRES: NA.24

Propriedades

• grau: certified reference material
• forma: liquid
• Características: Snap-N-Spike^®/Snap-N-Shoot^®
• embalagem: ampule of 1 mL
• fabricante/nome comercial: Cerilliant^®
• concentração: 1.0 mg/mL in methanol (as free base)
• técnica(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicação(ões): clinical testing
• formato: single component solution
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: IC1=CC(C(C2=C(CCCC)OC3=CC=CC=C23)=O)=CC(I)=C1OCCNCC.Cl
• InChI: 1S/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H
• chave InChI: OCQPMJVGWGJLLG-UHFFFAOYSA-N

Descrição

Descrição geral

A Certified Spiking Solution^® for use in therapeutic drug monitoring analyses by HPLC or LCMS. N-Desethylamiodarone is the primary, active metabolite of amiodarone, an antiarrhythmic agent marketed as Pacerone^®, Cordarone^®, Aratac, and Atlansil and monitored by clinical labs to ensure patients remain within the drugs therapeutic range.

Aplicação

• Impact on Amiodarone Absorption: A study examining the effects of probiotics on drug pharmacokinetics demonstrated that E. coli Nissle 1917 alters the absorption of amiodarone in rats, which suggests implications for N-Desethylamiodarone hydrochloride, a metabolite of amiodarone, in similar biochemical studies. This provides valuable insights for research into the metabolic pathways and interactions of amiodarone derivatives (Matuskova et al., 2014).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Cordarone is a registered trademark of Sanofi S.A.

Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H225,H301 + H311 + H331,H370
• Declarações de precaução: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Órgãos-alvo: Eyes
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 49.5 °F - closed cup
• Ponto de fulgor (°C): 9.7 °C - closed cup