D-011
1,3-Dinitroglycerin solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Fórmula empírica (Notação de Hill):
C3H6N2O7
Número CAS:
Peso molecular:
182.09
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24
Produtos recomendados
grau
certified reference material
Nível de qualidade
forma
liquid
Características
Snap-N-Spike®/Snap-N-Shoot®
embalagem
ampule of 1 mL
fabricante/nome comercial
Cerilliant®
concentração
1.0 mg/mL in acetonitrile
técnica(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
aplicação(ões)
pharmaceutical (small molecule)
formato
single component solution
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
OC(CO[N+]([O-])=O)CO[N+]([O-])=O
InChI
1S/C3H6N2O7/c6-3(1-11-4(7)8)2-12-5(9)10/h3,6H,1-2H2
chave InChI
ASIGVDLTBLZXNC-UHFFFAOYSA-N
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Descrição geral
1,3-Dinitroglycerin is a major plasma metabolite of the pharmaceutical vasodilator nitroglycerin. This Certified Spiking Solution® is suitable for use in chromatography or mass spectrometry-based applications in pharmaceutical research or clinical toxicology. Nitroglycerin is used to treat heart conditions such as angina and chronic heart failure.
Aplicação
- Population pharmacokinetics of nitroglycerin and of its two metabolites after a single 24-hour application of a nitroglycerin transdermal matrix delivery system: This study presents a comprehensive analysis on the population pharmacokinetics of nitroglycerin, focusing on its behavior and the behavior of its metabolites following the use of a transdermal delivery system. The findings contribute to understanding the systemic availability and action of nitroglycerin from such systems, which could be relevant for 1,3-Dinitroglycerin given its structural and functional similarities (Auclair et al., 1998).
- Novel pharmacokinetic modelling of transdermal nitroglycerin: This research explores advanced pharmacokinetic models that describe the absorption and action of nitroglycerin when administered through transdermal patches. Such models are crucial for developing effective transdermal delivery systems for similar compounds like 1,3-Dinitroglycerin (Auclair et al., 1998).
- Bioequivalence Comparison of Two Drug-in-Adhesive Transdermal Nitroglycerin Patches: This study compares the bioequivalence of two transdermal patches delivering nitroglycerin, highlighting the critical factors in the design and performance of transdermal systems that could similarly apply to 1,3-Dinitroglycerin (Harrison et al., 1996).
- Percutaneous absorption of 1,3-dinitroglycerin and a trial of pharmacokinetic analysis: Directly relevant to 1,3-Dinitroglycerin, this study examines its percutaneous absorption characteristics, offering insights into its potential applications in transdermal delivery systems (Ogiso et al., 1990).
- Analysis of solutions containing glutathione and inorganic nitrite: application to nitroglycerin metabolism studies: While primarily focused on nitroglycerin, this analysis could provide secondary insights into the metabolic pathways and interactions of 1,3-Dinitroglycerin with biomolecules like glutathione, which is crucial for understanding its pharmacological effects (Curry et al., 1987).
Informações legais
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Nº do produto
Descrição
Preços
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Código de classe de armazenamento
3 - Flammable liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
35.6 °F - closed cup
Ponto de fulgor (°C)
2 °C - closed cup
Certificados de análise (COA)
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B Auclair et al.
Pharmaceutical research, 15(4), 614-619 (1998-05-20)
To construct a pharmacokinetic (PK) model and to determine population PK parameters of nitroglycerin (GTN), 1,2-dinitroglycerin (1,2-GDN), and 1,3-dinitroglycerin (1,3-GDN). Data were obtained in thirty healthy volunteers following a single dose of a GTN reservoir transdermal patch. Blood samples were
B P Booth et al.
Anesthesia and analgesia, 78(5), 848-856 (1994-05-01)
Glyceryl trinitrate (GTN) is used to control arterial blood pressure during cardiopulmonary bypass (CPB) procedures, but its effects are often decreased during the period of extracorporeal support. The plasma and urine concentrations of GTN and glyceryl-1,2-dinitrate (1,2-GDN) and glyceryl-1,3-dinitrate (1,3-GDN)
Magnus Petersson et al.
Clinical physiology and functional imaging, 28(4), 229-234 (2008-04-04)
Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal. Two pathways leading to biotransformation of GTN have been characterized; a high-affinity pathway
B P Booth et al.
Canadian journal of physiology and pharmacology, 71(8), 629-632 (1993-08-01)
It has previously been shown that the vasodilatory response to glyceryl trinitrate (GTN) was decreased during hypothermic cardiopulmonary bypass. The purpose of these experiments was to determine the effect of temperature on GTN-induced relaxation and on GTN biotransformation in rabbit
T Kikkoji et al.
Pharmaceutical research, 8(10), 1231-1237 (1991-10-01)
The percutaneous penetration kinetics of the antianginal, nitroglycerin (GTN), and its primary metabolites, 1,2- and 1,3-glyceryl dinitrate (1,2- and 1,3-GDN), were evaluated in vitro, using full-thickness hairless mouse skin. GTN and the 1,2- and 1,3-GDNs were applied (a) in aqueous
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